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[Association of the vertebral artery with cardiovascular disease risk factors in middle-aged and elderly individuals.]

I T MurkamilovI.K.Akhunbaev Kyrgyz State Medical Academy, 92 str. Akhunbaev, Bishkek720020, Kyrgyzstan, e-mail: [email protected]K A AitbaevInstitution «Salymbekov University» 144 Bokonbayev str., Bishkek 720040, KyrgyzstanV V FominRussian Medical Academy of Continuous Professional Education, 2/1 Barrikadnaya str., Moscow 125993, Russian FederationZ A MurkamilovaFamily Medicine Center № 7, 3 str. T. Moldo, Bishkek 720040, KyrgyzstanZ R RayimzhanovN.N.Burdenko Hospital, 3 Hospital square, Moscow 105094, Russian FederationI U AbdurakhmanovSaint-Petersburg State University, 7-9 Universitetskaya naberezhnaya, St. Petersburg 199034, Russian FederationJ I SolizhonovRepublican Specialized Scientific and Practical Medical Center for Nephrology and Kidney Transplantation, 3d Road 6-th Yangi Shahar, Tashkent 100058, UzbekistanA F YusupovOsh State University, 331 Lenin str., Osh 723500, KyrgyzstanT F YusupovaOsh State University, 331 Lenin str., Osh 723500, KyrgyzstanZ F YusupovaOsh State University, 331 Lenin str., Osh 723500, KyrgyzstanF A YusupovOsh State University, 331 Lenin str., Osh 723500, KyrgyzstanA I SabirovaKyrgyz Russian Slavic University named after B.N.Yeltsin, 44 Kiev str., Bishkek 720011, Kyrgyzstan

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Abstract

Objective - to assess the association between structural changes in the vertebral arteries and cardiovascular disease risk factors in middle-aged and elderly individuals. The study included 387 patients (196 men and 191 women) aged 45-74 years (mean age 57,7±7,3 years) from a therapeutic profile. Vertebral artery parameters, anthropometric, hemodynamic, and biochemical indicators, as well as the prevalence of cardiovascular risk factors, were analyzed in middle-aged (n=225) and elderly (n=162) groups. Elderly patients had significantly higher mean values of systolic and diastolic blood pressure, serum creatinine concentration, and lower estimated glomerular filtration rate (eGFR) compared to middle-aged patients. The prevalence of arterial hypertension (66% vs. 44,8%, p<0,05), chronic kidney disease (32,1% vs. 18,2%, p<0,05), anemia (27,7% vs. 14,2%, p<0,05), and hyperglycemia (22,2% vs. 5,3%, p<0,05) was significantly higher in the elderly group. A reduction in the internal diameter of the right and left vertebral arteries was observed in 13,7% and 9,7% of middle-aged patients, respectively, and in 13,5% and 4,3% of elderly patients. Vertebral artery diameter correlated with age (r=-0,217), body mass index (r=0,152), red blood cell count (r=0,197), total cholesterol concentration (r=-0,138), low-density lipoprotein cholesterol (r=-0,125), high-density lipoprotein cholesterol (r=-0,129), and estimated eGFR (r=-0,188). In elderly patients, significant cardiovascular risk factors include increased blood pressure, anemia, hyperglycemia, and decreased glomerular filtration rate. To improve the effectiveness of secondary prevention of cardiovascular complications, regular monitoring of hemodynamic parameters, blood glucose levels, and kidney function should be performed, considering the condition of the vertebral arteries.

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