THE SIGNIFICANCE OF DRIVER GENE MUTATIONS JAK2, CALR, AND MPL IN CHRONIC MYELOPROLIFERATIVE DISEASES
Beknur Bobir ugli GiyosovSamarkand State Medical University, Samarkand, UzbekistanKodirjon Tukhtaboevich BoboevRepublican Specialized Scientific-Practical Medical Center of Hematology, Tashkent, UzbekistanFeruz Asatullaevich DaminovSamarkand State Medical University, Samarkand, Uzbekistan
Zenodo (CERN European Organization for Nuclear Research)repository2026
ABI
Abstract
Resume. Driver mutations in the JAK2, CALR, and MPL genes play a crucial role in the diagnosis of myeloproliferative disorders, enabling accurate identification of their type and exclusion of other diseases with similar symptoms. Purpose. To determine the role of driver gene mutations (JAK2, CALR, and MPL) in chronic myeloproliferative neoplasms (MPNs), including their significance in pathogenesis, diagnosis, and clinical management. Keywords: Myeloproliferative diseases, diagnosis, driver genes: JAK2, CALR, MPL
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