T786C AND GLU298ASP Polymorphisms Of The Nos3 Gene And Their Association With Vascular Dysfunction In Patients With Coronary Heart Disease And Type 2 Diabetes Mellitus
Abdullaeva Charos AbdujalilovnaJuraev Mirzo IbodulloevichZaxidova Mamura UmidjanovnaTashkent State Medical University , UzbekistanMullaeva Sayyora Ilhomjonovna
ABI
Abstract
The impact of the T786C and Glu298Asp polymorphisms of the NOS3 gene on vascular reactivity parameters was assessed in patients with coronary artery disease and type 2 diabetes mellitus. Ninety-two patients were examined and genotyping was performed using PCR. Average linear blood flow velocity, arterial diameters before and after the functional test, and resistance and reactivity coefficients were studied. A significant decrease in vascular reactivity was found in carriers of the T/C and Glu/Asp genotypes compared to homozygotes. The identified patterns highlight the importance of NOS3 polymorphisms in the pathogenesis of vascular disorders in the combination of coronary heart disease and type 2 diabetes.
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