Article

AGE-RELATED HISTOLOGICAL CHANGES IN CARDIAC MUSCLE TISSUE

Shahzoda JumayevaTashkent Medical University, Termez BranchShoxrullo SaidovTermez Medical University Assistant Lecturer, Department of Histology

Zenodo (CERN European Organization for Nuclear Research)repository2026en

ABI

Abstract

Age-related changes in cardiac muscle tissue represent an important morphological basis for the development of cardiovascular diseases in the elderly. This study aims to analyze histological alterations of myocardial tissue associated with aging, with particular attention to structural, cellular, and interstitial modifications. Histological examination revealed progressive hypertrophy of cardiomyocytes, a reduction in the regenerative capacity of muscle fibers, and an increase in connective tissue components with advancing age. Additionally, age-related degeneration of myofibrils, accumulation of lipofuscin granules, and changes in nuclear morphology were observed.

Topics

Muscle Physiology and Disorders Cardiac Fibrosis and Remodeling Cardiomyopathy and Myosin Studies

Identifiers

DOI: 10.5281/zenodo.18613421

Citations and references

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