Article

PSEUDOMONAS AERUGINOSA BIOPHIL FORMATION MECHANISMS AND ANTIBIOTIC RESISTANCE RELATING TO CURRENT ISSUES

Buriyev Muhammadali Gayrat ogluTermez University of Economics and Service Faculty of Medicine Department of Medical Preventive Sciences Lecturer in MicrobiologyAkhmedov Ulugbek Xolbek ogluTermez University of Economics and Service, Department of Fundamental Medical Sciences, AssistantKhushboqov Shohruh Ulug'bek ogluTermez University of Economics and Service Student of the Faculty of Medicine

Zenodo (CERN European Organization for Nuclear Research)repository2026en

ABI

Abstract

Pseudomonas aeruginosa is an opportunistic pathogen that forms biofilms and is highly resistant to antibiotics. This study investigated the steps of bifilm formation, the mechanism of quorum sensing, and the antibiogram profile using a novel approach. Crystal violet assay and MIC detection methods were used to determine the 72-hour biofilm density (OD 0.912) and 10–128-fold resistance to antibiotics. Furanone-AHL quorum sensing inhibitor was shown to have an 80% biofilm reduction effect. The results provide a basis for a biofilm-fighting strategy as a promising solution for QS-opponent therapy.

Topics

Bacterial biofilms and quorum sensing Infections and bacterial resistance Legionella and Acanthamoeba research

Identifiers

DOI: 10.5281/zenodo.18635506

Citations and references

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