Application of the method of mathematical planning for the selection of auxiliary components for the creation of a functional-purpose medicinal and cosmetic product
Abstract
The aim of the research: selection of the optimal complex of excipients and development of technology for a therapeutic and cosmetic cream for the acne treatment. Materials and methods. The following active pharmaceutical ingredients were selected - the dry extract of "Fitoinflam," nicotinamide, salicylic acid, and camphor. Twenty ingredients were used as excipients, acting as a structure-forming agent, emulsifier, emollient, or oil phase. Excipient selection was conducted using a four-factor design based on a 5x5 Greco-Latin square. In vitro studies were conducted using equilibrium dialysis through a semipermeable membrane according to Kruvchinsky. Quantification of total flavonoids, expressed as rutin, was determined by high-performance liquid chromatography. Results. Using Duncan's ranking test, the most optimal excipients for the cream under development were determined: aerosil (structuring agent), sodium tetraborate (emulsifier), glycerin (emollient), and castor oil (oil medium). The concentration of citric acid as a pH regulator was selected empirically: according to the data obtained, the optimal concentration was 1%. Conclusions. Based on the results of an experimental design using a 5x5 Greco-Latin square layout, a composition for a medicated, emulsion-type anti-acne cream was developed: dry extract of "Phytoinflam," nicotinamide, salicylic acid, camphor, aerosil, sodium tetraborate, glycerin, castor oil, citric acid, tea tree essential oil, and purified water. A technology for producing cosmetic cream was developed based on the physicochemical properties of the active pharmacological substances and excipients