Primary Chronic Brucellosis in Children: Between Infection and Immunity

Abstract

Clinical and immunological examinations of 19 patients showed that in children with the primary chronic form of brucellosis, the clinical picture of the disease was characterized by its diversity and was distinguished by a slightly milder course compared to the acute and subacute forms of brucellosis. Immunological studies in these patients revealed an imbalance in the cellular immunity, where an increase in leukocytes and lymphocytes was observed against a background of a sharp decrease in T-lymphocyte subpopulations (CD3+, CD4+, CD8+) compared to the control group. Imbalances were also observed in B-lymphocytes, the humoral immune system, and the cytokine group of the immune system.

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DOI

10.37547/ijmsphr/volume07issue02-12

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