PATHOGENETICALLY BASED CONSERVATIVE THERAPY IN THE COMPLEX TREATMENT OF ACUTE ADHESIVE SMALL BOWEL OBSTRUCTION
Abstract
PATHOGENETICALLY BASED CONSERVATIVE THERAPY IN THE COMPLEX TREATMENT OF ACUTE ADHESIVE SMALL BOWEL OBSTRUCTION Choriev Khaitmurod Kultura ugli, Mustafakulov Ishnazar Boynazarovich, Djuraeva Zilola Aramovna Samarkand State Medical University and the Termez Branch of Tashkent State Medical University https://doi.org/10.5281/zenodo.19093569 Abstract: Acute adhesive small bowel obstruction (ASBO) remains one of the most common causes of emergency abdominal surgery and is characterized by a high risk of complications and recurrence. Conservative treatment is effective only in some patients, and the lack of a pathogenetic approach limits its results. This study utilized a diagnostic algorithm using clinical, laboratory, and instrumental criteria. The use of a comprehensive conservative approach was associated with favorable clinical outcomes and improved motor-evacuation function, as measured by laboratory, radiographic, and ultrasound examinations. Post-treatment duplex ultrasound imaging revealed statistically significantly higher Vmax and Vmin values in patients with localized adhesions compared to those with widespread adhesions (p<0.001). This pathogenetically substantiated comprehensive conservative therapy is an effective component of OSTKO treatment and can be used to increase the rate of successful non-surgical resolution of the disease and optimize the choice of subsequent treatment. Keywords: acute adhesive small bowel obstruction, conservative therapy, serotonin adipate, oxidative stress, cytokines, microcirculation, ultrasound duplex scanning.