Efficacy and Safety Of D-, L-Hopanthenic Acid (Pantogam Active) In the Correction of Cognitive and Emotional Disorders in Patients with Arterial Hypertension
Abstract
This study presents the results of evaluating the efficacy and safety of the next-generation nootropic Pantogam Active (D-, L-hopantenic acid) in the comprehensive therapy of 80 patients with arterial hypertension accompanied by cognitive and anxiety disorders. It was found that administration of the drug at a dose of 600–1200 mg/day for 28 days provided a significant improvement (p < 0.05) in cognitive functions, as evidenced by increased scores on the MoCA and MMSE scales, as well as enhanced attention span and memory capacity. The drug demonstrated pronounced anxiolytic effects, reducing anxiety levels on the HADS scale by 32%, exceeding the outcomes of standard antihypertensive therapy. Pantogam Active showed a high safety profile and good tolerability, supporting its recommendation as an effective bimodal agent for neuroprotection and correction of psycho-emotional status in patients with chronic cerebrovascular diseases.