ASSOCIATION OF HELICOBACTER PYLORI–ASSOCIATED GASTRIC AND DUODENAL PEPTIC ULCER DISEASE WITH VITAMIN D DEFICIENCY
Mehrangiz IsmoilovaBukhara State Medical Institute, Uzbekistan, BukharaM IsmatovaBukhara State Medical Institute, Uzbekistan, BukharaI AbdulkhakovBukhara State Medical Institute, Uzbekistan, Bukhara
Scientific and Innovative Therapyjournal2026
ABI
Abstract
The pathophysiology of peptic ulcer disease (PUD) develops as a result of a complex multifactorial interaction between gastric acid secretion, the integrity of the mucosal protective barrier, Helicobacter pylori infection, and the modulatory effects of various nutrients on ulcer development and severity. Vitamin D₃ deficiency, which plays a crucial role in immune system function, may contribute to a more severe course of the disease. A clear association has been identified between vitamin D₃ deficiency and Helicobacter pylori infection, with a higher prevalence of infection observed among individuals with obesity, as well as among smokers and those who regularly consume fast food.
Topics
Identifiers
Citations and references
Cited by 00 references
Metrics — AkademScholar · Coming soon