SYNTHESIS OF AMIDE DERIVATIVES BASED ON GLYCYRETHIC ACID BY EDCI/HOBT ACTIVATION WITH 3-AMINOPROPYL IMIDAZOL
Turlibekov Diyorbek2nd-year Master's Student National University of UzbekistanXabibulla YuldashevSenior Researcher, Candidate of Chemical Sciences (PhD) Institute of Bioorganic Chemistry, Academy of Sciences of Uzbekistan
Zenodo (CERN European Organization for Nuclear Research)repository2026
ABI
Abstract
in this work, new amide derivatives were synthesized with 3-aminopropyl imidazole (3-API) by activating the carboxyl group of glycyrrhizic acid (GlC) in the presence of EDCI (1-ethyl-3- (3-dimethylaminopropyl) carbodiimide hydrochloride) and HOBt (1-hydroxybenzotriazole). The reaction was carried out in an inert gas medium, and the synthesis was carried out with a high chemical total (95%). [1] The resulting compound was confirmed using IR and mass spectrometry. The formation of the amide bond was determined by the absorption bands 1642 (C=O) and 3354 cm-1 (N-H). The results show that the EDCI/HOBt system is an effective reagent combination for amide synthesis based on natural triterpenoids.
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