Article

Autoimmune inflammation as a cause-and-effect relationship between periodontitis and atherosclerosis

Nazokat AsilbekovaSamarkand State Medical University Samarkand, UzbekistanIrina AgababiyanSamarkand State Medical University Samarkand, Uzbekistan

Zenodo (CERN European Organization for Nuclear Research)repository2026

ABI

Abstract

The role of inflammatory factors (ICAM-1, VCAM-1) and cytokines (INF-γ, TNF-α, IL-1) in the development of chronic heart failure (CHF) is analyzed in this study. It highlights the systemic inflammatory processes occurring in patients with periodontitis due to the entry of periodontal pathogens, such as P. gingivalis and T. forsythia, into the circulatory system. Furthermore, it is substantiated that the elevation of interleukin levels (IL-6, IL-8) and C-reactive protein (CRP) caused by periodontitis accelerates cardiomyocyte damage.

Topics

Oral microbiology and periodontitis research Salivary Gland Disorders and Functions Oral and gingival health research

Identifiers

DOI: 10.5281/zenodo.19970279

Citations and references

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