Article

Prevalence and epidemiology of hepatitis B and hepatitis D in Uzbekistan—results from a population-based serosurvey, 2022

Erkin MusabaevResearch Institute of Virology of the Republican Specialized Scientific and Practical Medical Center of Epidemiology, Microbiology, Infectious and Parasitic Diseases, Tashkent, UzbekistanRania A. TohmeDivision of Viral Hepatitis, Centers for Disease Control and Prevention, Atlanta, GA, USAElizaveta JoldasovaIntegral Global Health, Tashkent, UzbekistanShakhida KaramatovaDivision of Global Health Protection, Centers for Disease Control and Prevention, Uzbekistan Country Office, Tashkent, UzbekistanAybek KhodievDivision of Global Health Protection, Centers for Disease Control and Prevention, Uzbekistan Country Office, Tashkent, UzbekistanNataliya KanResearch Institute of Virology of the Republican Specialized Scientific and Practical Medical Center of Epidemiology, Microbiology, Infectious and Parasitic Diseases, Tashkent, UzbekistanAbdulaziz AbdurasulovResearch Institute of Virology of the Republican Specialized Scientific and Practical Medical Center of Epidemiology, Microbiology, Infectious and Parasitic Diseases, Tashkent, UzbekistanMalika KhodjaevaResearch Institute of Virology of the Republican Specialized Scientific and Practical Medical Center of Epidemiology, Microbiology, Infectious and Parasitic Diseases, Tashkent, UzbekistanBotirjon KurbanovCommittee for Sanitary and Epidemiological Welfare and Public Health, Ministry of Health of the Republic of Uzbekistan, Tashkent, UzbekistanZulfiya AbdurakhimovaCommittee for Sanitary and Epidemiological Welfare and Public Health, Ministry of Health of the Republic of Uzbekistan, Tashkent, UzbekistanDilafkor MirdjalilovDivision of Global Health Protection, Centers for Disease Control and Prevention, Uzbekistan Country Office, Tashkent, UzbekistanSaleem KamiliDivision of Viral Hepatitis, Centers for Disease Control and Prevention, Atlanta, GA, USAShaun ShadakerDivision of Viral Hepatitis, Centers for Disease Control and Prevention, Atlanta, GA, USANino KhetsurianiDivision of Viral Hepatitis, Centers for Disease Control and Prevention, Atlanta, GA, USA

IJID Regionsjournal2026en

ABI

Abstract

Objectives: Uzbekistan, historically a country with high hepatitis B virus (HBV) infection endemicity, introduced infant hepatitis B vaccination in 2001 and has sustained ≥90% coverage for hepatitis B vaccine birth dose (HepB-BD) and three or more doses. In 2017, Uzbekistan initiated hepatitis B elimination activities. However, data on hepatitis B prevalence in the general population were lacking. Methods: In 2022, we conducted a serosurvey among persons aged ≥5 years using stratified cluster sampling. Blood samples were tested for markers of HBV and hepatitis D virus (HDV) infections. Results: < 0.001). Conclusion: Successful hepatitis B vaccination resulted in low HBV infection prevalence among children, but hepatitis B remains widespread among adults in Uzbekistan. Expanding HBV prevention, screening, and treatment among adults, and maintaining high infant vaccination coverage may help achieve hepatitis B elimination in Uzbekistan.

Topics

Hepatitis B Virus Studies Hepatitis Viruses Studies and Epidemiology Hepatitis C virus research

Identifiers

DOI: 10.1016/j.ijregi.2026.100910

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