Study Of The Fundamentals For Developing A Cream Formulation Based On Zinc Oxide Nanoparticles
Abstract
This article presents a review of contemporary approaches to the development of creams containing zinc oxide nanoparticles. The physicochemical and pharmacological properties of ZnO nanoparticles (ZnO NPs), including their antimicrobial, anti-inflammatory, and wound-healing activities, are discussed. Particular attention is paid to the interaction of nanoparticles with the skin, as well as to the factors influencing their stability and bioavailability. Special emphasis is placed on the selection of an optimal cream base (O/W and W/O systems), the role of excipients, and the technological aspects involved in obtaining stable dosage forms. The generalization of literature data makes it possible to identify the key parameters required for the development of effective and safe creams containing zinc oxide nanoparticles.