Morphofunctional Changes In The Flower's Tube Bones Under Maternal Prenatal Stress
Abstract
This study examined the impact of prenatal immobilization stress on the development of the offspring's tubular bones. Experiments were conducted on white rats; during pregnancy, females were subjected to stress for 2 hours a day for 14 days. According to the results obtained, it was found that in the generations of the stress group, the femoral length decreased by 11.7%, the thickness of the diaphysis by 21.4%, and the thickness of the epiphyseal plate by 17.9%. A decrease in the number of osteocytes by 24.3% and bone mineralization by 18.9% was also noted (p<0.05). These changes are explained by the suppression of endochondral osteogenesis, a decrease in chondrocytal proliferation, and a decrease in osteoblast activity. The results indicate the complex negative impact of prenatal stress on bone tissue, confirming that it can increase the risk of osteopenia and skeletal deformities in later developmental stages. The research results substantiate the necessity of developing preventive measures and controlling stress during the prenatal period.