ASSESSMENT OF THE RELATIONSHIP BETWEEN PROLACTIN VALUES AND LIPID PROFILE IN PATIENTS WITH GESTATIONAL HYPERTENSION
Abstract
Objective: to identify presence of relationship between lipid profile and prolactin value in pregnant women with gestational arterial hypertension (GHT) Design and method: 91 pregnant women, divided into 2 groups. Group 1 (n=47) of pregnant women with GHT. Group 2 (n=44) of healthy group. All pregnant women underwent physical examination, BP measurement, BMI was calculated and analysis of lipid spectrum was performed. Prolactin levels were analyzed. Statistical processing was performed using Statistica 13.0 program. P <0.05 was considered statistically significant. Results: Groups were comparable in age 31±6.7 in group 1 versus 30±6.7 (P=0.4786), in gestational age 29±3.86 versus 28±2.4 (P=0.1445), in BMI 30±4.45 kg/m2 versus 29±4.87 (P=0.3088). Average BP in GHT group corresponded to moderately elevated BP(2018 ESC Guidelines for management of cardiovascular diseases during pregnancy), amounting to SBP 151.83±9.98 mmHg in gr 1 versus 126.02±6.58 mmHg in gr 2 (P<0.0001). According to DBP 96.16 ± 7.62 mmHg versus 76.77 ± 7.8 mmHg in group 2 (P < 0.0001). Heart rate in gr 1 was 89.8 ± 12.2 beats/min and in 2 group 93.5 ± 13.8 beats/min (P = 0.22). Analysis of lipid spectrum showed that women with GHT had significantly higher parameters of total cholesterol, triglycerides, low- and high-density lipoproteins than healthy group, regardless of BMI parameters. Total cholesterol 187 ± 39 mg/dl vs 146 ± 35 in group 2 (P < 0.0001); triglycerides were 182 ± 40.8 mg/dl vs 123 ± 100.8 (P < 0.0004); LDL was 125±35.6 mg/dl vs 84±14.8 (P <0.0001); HDL was 34±11 mg/dl vs 50±15 (P <0.0001). At the same time, none of pregnant women had history of lipid metabolism disorders before pregnancy. The level of prolactin, although not exceeding normal values, was significantly higher in group with GHT, amounting to 6105±1192.3 uU/ml than in healthy women, 3118±896.5 uU/ml, respectively. Conclusions: Thus, we do not exclude relationship between lipid profile disorders and prolactin levels in pregnant women with GHT. At the same time, such relationship did not depend on BMI and gestational age, which leads us to idea of the influence of prolactin levels on lipid indices in pregnant women.