Article

Preparation of berberine micelles and its anti-skin damage in hyperglycemia mice

Xingcheng JinDepartment of Pharmacy, the Second Affiliated Hospital of Anhui Medical UniversityQinyang HuaDepartment of Pharmaceutics, School of Pharmacy, Center for Nano Drug/Gene Delivery and Tissue Engineering, Jiangsu Provincial Research Center for Medicinal Function Development of New Food Resources, Jiangsu UniversityMichael Adu‐FrimpongDepartment of Biochemistry and Forensic Science, School of Chemical and Biochemical Sciences, C. K. Tedam University of Technology and Applied Sciences (CKT-UTAS)Q. LiDepartment of Pharmaceutics, School of Pharmacy, Center for Nano Drug/Gene Delivery and Tissue Engineering, Jiangsu Provincial Research Center for Medicinal Function Development of New Food Resources, Jiangsu UniversityQilong WangDepartment of Pharmaceutics, School of Pharmacy, Center for Nano Drug/Gene Delivery and Tissue Engineering, Jiangsu Provincial Research Center for Medicinal Function Development of New Food Resources, Jiangsu UniversityElmurat ToreniyazovInstitute of Agriculture and Agrotechnologies of KarakalpakstanXia CaoDepartment of Pharmaceutics, School of Pharmacy, Center for Nano Drug/Gene Delivery and Tissue Engineering, Jiangsu Provincial Research Center for Medicinal Function Development of New Food Resources, Jiangsu UniversityJiangnan YuDepartment of Pharmaceutics, School of Pharmacy, Center for Nano Drug/Gene Delivery and Tissue Engineering, Jiangsu Provincial Research Center for Medicinal Function Development of New Food Resources, Jiangsu UniversityXiming XuDepartment of Pharmaceutics, School of Pharmacy, Center for Nano Drug/Gene Delivery and Tissue Engineering, Jiangsu Provincial Research Center for Medicinal Function Development of New Food Resources, Jiangsu University

Xenobioticajournal2026en

ABI

Abstract

release of berberine from micelles was higher than that of free berberine across all tested media.Pharmacokinetic studies in rats showed that berberine micelles prolonged the half-life from 5.77 h to 12.19 h and extended the mean retention time from 20.74 h to 143.31 h, with a relative bioavailability 2.64‑fold greater than that of free berberine.In a streptozotocin‑induced hyperglycaemic mouse skin injury model, the high‑dose berberine micelle group significantly accelerated wound closure compared to the free drug group on days 6 and 9, and histopathological analysis of skin, liver, spleen, and pancreas revealed superior tissue recovery. These findings suggest that berberine micelles effectively enhance the anti‑hyperglycaemic and skin‑repairing efficacy of berberine.

Topics

Berberine and alkaloids research Advancements in Transdermal Drug Delivery Alkaloids: synthesis and pharmacology

Identifiers

DOI: 10.1080/00498254.2026.2683638

Citations and references

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