CYTOKINE PROFILE IN MICROVASCULAR ANGINA: CLINICAL AND DIAGNOSTIC SIGNIFICANCE
Abstract
Relevance. Microvascular angina (MSA) is one of the most common forms of coronary heart disease with an unfavorable prognosis. Immunoinflammatory mechanisms play a key role in its pathogenesis. The aim of the study was to evaluate the cytokine profile in patients with microvascular angina and determine its diagnostic significance. Materials and methods. A total of 86 patients were examined: the main group (n=46) - patients with MSA, the control group - apparently healthy individuals. The levels of interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α) and high-sensitivity C-reactive protein (hsCRP) in the serum were determined. Results. In patients with MSA, a significant increase in the concentration of IL-6 by 2.3 times, TNF-α by 1.8 times and hsCRP by 2.1 times was revealed compared to the controls. A direct correlation was found between cytokine levels and the severity of clinical manifestations. Conclusion: The cytokine profile can serve as an additional diagnostic criterion for microvascular angina and an objective marker of inflammatory activity.