Repertoires of Autophagy in the Pathogenesis of Ocular Diseases
Yujie LiEye Hospital, Nanjing Medical University, Nanjing, ChinaQin JiangEye Hospital, Nanjing Medical University,Guo-Fan CaoEye Hospital, Nanjing Medical University,Jin YaoEye Hospital, Nanjing Medical University,Biao YanEye Hospital, Nanjing Medical University,
2015en
ABI
Abstract
Autophagy is an important intracellular degradative process that delivers cytoplasmic proteins to lysosome for degradation. Dysfunction of autophagy is implicated in several human diseases, such as neurodegenerative diseases, infectious diseases, and cancers. Autophagy-related proteins are constitutively expressed in the eye. Increasing studies have revealed that abnormal autophagy is an important pathological feature of several ocular diseases. Pharmacological manipulation of autophagy may provide an alternative therapeutic target for some ocular diseases. In this manuscript, we reviewed the relevant progress about the role of autophagy in the pathogenesis of ocular diseases.
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Cited by 30 references