Synthesis and biological evaluation of thieno[2,3-d]pyrimidine derivatives for anti-inflammatory, analgesic and ulcerogenic activity
Abdel-Rahman B.A. El-GazzarPhotochemistry Department (Heterocyclic Unit), National Research Center, Dokki, Giza, EgyptHoda A. R. HusseinPhotochemistry Department (Heterocyclic Unit) National Research Center Dokki, Giza, EgyptHend N. HafezPhotochemistry Department (Heterocyclic Unit) National Research Center Dokki, Giza, Egypt
2007en
ABI
Abstract
Synthesis and biological evaluation of thieno[2,3- d ]pyrimidine derivatives for anti-inflammatory, analgesic and ulcerogenic activity 5-Methyl-6-phenyl-2-thioxothieno[2,3- d ]pyrimidone derivative ( 2 ) reacted with hydrazonoyl chloride derivatives to afford triazolothienopyrimidones 4a-f. Also, acetone-1-(2-amino-5-isopropyl-thiophene-3-carbonitrile) ( 3 ) reacted with functional and bifunctional groups to yield the corresponding compounds 5-11 . The new products showed anti-inflammatory, analgesic, and ulcerogenic activities comparable to that of indomethacin and acetylsalicylic acid, respectively.
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