Synthesis, Characterization and Biological Studies of Some Novel Thieno[2,3-d]pyrimidines
Khulud M. Al-TaisanChemistry Department, College of Science, King Faisal University, P.O. Box 400, Hofuf 31982, Saudi ArabiaH.M.A. Al-HazimiChemistry Department, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi ArabiaShar S. Al‐ShihryChemistry Department, College of Science, King Faisal University, P.O. Box 400, Hofuf 31982, Saudi Arabia
2010en
ABI
Abstract
Several 2-unsubstituted thieno[2,3-d]pyrimidines have been prepared from 2-aminothiophene-3-carboxylic acid esters and their carbonitrile analogs. Some triazolo-thienopyrimidine and 2-thioxothienopyrimidine representatives have also been synthesized using thermal and microwave (MW) irradiation techniques. Structures of the prepared compounds were elucidated on the basis of IR, NMR, 2D NMR and mass spectral data. The biological activity of some selected synthesized compounds was also examined.
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