INDUCTION OF BREAST AND LUNG NEOPLASTIC LESIONS IN MICE BY ALPHA-ECDYSONE
el-Mofty MmMENOUFIA UNIV,FAC SCI,DEPT ZOOL,SHIBIN AL KAWM,EGYPT. UNIV ALEXANDRIA,FAC MED,DEPT PATHOL,ALEXANDRIA,EGYPTSa. SakrMENOUFIA UNIV,FAC SCI,DEPT ZOOL,SHIBIN AL KAWM,EGYPT. UNIV ALEXANDRIA,FAC MED,DEPT PATHOL,ALEXANDRIA,EGYPTAM RIZKMENOUFIA UNIV,FAC SCI,DEPT ZOOL,SHIBIN AL KAWM,EGYPT. UNIV ALEXANDRIA,FAC MED,DEPT PATHOL,ALEXANDRIA,EGYPTEA MOUSSAMENOUFIA UNIV,FAC SCI,DEPT ZOOL,SHIBIN AL KAWM,EGYPT. UNIV ALEXANDRIA,FAC MED,DEPT PATHOL,ALEXANDRIA,EGYPT
1994en
ABI
Abstract
Alpha ecdysone is naturally present in the leaves of some plants, including the carcinogenic plant bracken fern (Pteris aquilina). Feeding mice with alpha-ecdysone at a dose level of 3 ppm/25 g body weight, 2 times per week for 22 months induced a significant increase in the body weight of the animals. Breast and lung tumors developed in the experimental mice. Other pathological changes such as fibrocystic disease of the breast and bronchocentric granulomas appeared in these animals. The results of this study proved that alpha-ecdysone may be one of the active carcinogens in bracken fern plant which was responsible for induction of tumors in different animals investigated by previous authors.
Identifiers
Citations and references
Cited by 20 references