5‐Alpha‐ and 5‐beta‐2‐deoxyintegristerone A, a 5‐alpha and 5‐beta isomer pair of ecdysteroids isolated from the <i>Silene</i> genus
Mária BáthoriDepartment of Pharmacognosy, University of Szeged, 6701 Szeged, Eötvös utca 6, PO Box 121, HungaryHuba KalászDepartment of Pharmacology, Semmelweis University, H-1445 Budapest, Nagyvárad tér 4, PO Box 370, HungaryZita PongráczDepartment of Pharmacognosy, University of Szeged, 6701 Szeged, Eötvös utca 6, PO Box 121, HungaryImre MáthéDepartment of Pharmacognosy, University of Szeged, 6701 Szeged, Eötvös utca 6, PO Box 121, HungaryAlajos KálmánInstitute of Chemistry, Chemical Research Center of the Hungarian Academy of Sciences, Budapest, HungaryGyula ArgayInstitute of Chemistry, Chemical Research Center of the Hungarian Academy of Sciences, Budapest, Hungary
2002en
ABI
Abstract
5-Alpha-2-deoxyintegristerone A and 5-beta-2-deoxyintegristerone A were isolated from the aerial parts of Silene italica ssp. nemoralis (Waldst. and Kit.) Nyman using a specific combination of absorption column chromatography, preparative thin-layer chromatography and preparative HPLC. Both normal-phase and reversed-phase modes of HPLC were employed for isolation. Structural elucidation of 5-alpha-2-deoxyintegristerone A was completed by X-ray diffraction. Both 5-alpha-2-deoxyintegristerone A and 5-beta-2-deoxyintegristerone A were firstly isolated from this plant. We propose that 5-alpha-2-deoxyintegristerone A is not an artifact but an integral part of the ecdysteroid spectrum of Silene italica ssp. nemoralis (Waldst. and Kit.) Nyman.
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