Identification and Characterization of a Prostaglandin Transporter
Naoaki KANAIRenal Division, Department of Medicine and Department of Physiology and Biophysics, Albert Einstein College of Medicine, Bronx, NY 10461, USARun LuRenal Division, Department of Medicine and Department of Physiology and Biophysics, Albert Einstein College of Medicine, Bronx, NY 10461, USAJoseph SatrianoRenal Division, Department of Medicine and Department of Physiology and Biophysics, Albert Einstein College of Medicine, Bronx, NY 10461, USAYi BaoRenal Division, Department of Medicine and Department of Physiology and Biophysics, Albert Einstein College of Medicine, Bronx, NY 10461, USAAllan W. WolkoffMarion Bessin Liver Research Center and Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USAVictor L. SchusterRenal Division, Department of Medicine and Department of Physiology and Biophysics, Albert Einstein College of Medicine, Bronx, NY 10461, USA
1995en
ABI
Abstract
Carrier-mediated prostaglandin transport has been postulated to occur in many tissues. On the basis of sequence homology, the protein of unknown function encoded by the rat matrin F/G complementary DNA was predicted to be an organic anion transporter. Expression of the matrin F/G complementary DNA in HeLa cells or Xenopus oocytes conferred the property of specific transport of prostaglandins. The tissue distribution of matrin F/G messenger RNA and the sensitivity of matrin F/G-induced prostaglandin transport to inhibitors were similar to those of endogenous prostaglandin transport. The protein encoded by the matrin F/G complementary DNA is thus preferably called PGT because it is likely to function as a prostaglandin transporter.
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