Article

Cycloartane Triterpene Glycosides from the Roots of <i>Astragalus brachypterus</i> and <i>Astragalus microcephalus</i>

Erdal BedіrDepartment of Pharmacognosy, Faculty of Pharmacy, Hacettepe University, TR-06100 Ankara, Turkey, and Facoltà di Farmacia, Università degli Studi di Salerno, 84084 Penta di Fisciano, Salerno, Italyİhsan ÇalışDepartment of Pharmacognosy, Faculty of Pharmacy, Hacettepe University, TR-06100 Ankara, Turkey, and Facoltà di Farmacia, Università degli Studi di Salerno, 84084 Penta di Fisciano, Salerno, ItalyRita Patrizia AquinoDepartment of Pharmacognosy, Faculty of Pharmacy, Hacettepe University, TR-06100 Ankara, Turkey, and Facoltà di Farmacia, Università degli Studi di Salerno, 84084 Penta di Fisciano, Salerno, ItalySonia PiacenteDepartment of Pharmacognosy, Faculty of Pharmacy, Hacettepe University, TR-06100 Ankara, Turkey, and Facoltà di Farmacia, Università degli Studi di Salerno, 84084 Penta di Fisciano, Salerno, ItalyCosimo PìzzaDepartment of Pharmacognosy, Faculty of Pharmacy, Hacettepe University, TR-06100 Ankara, Turkey, and Facoltà di Farmacia, Università degli Studi di Salerno, 84084 Penta di Fisciano, Salerno, Italy

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Abstract

Three new cycloartane-type triterpene glycosides, brachyosides A (1), B (3), and C (2), from the roots of Astragalus brachypterus and one new glycoside, cyclocephaloside II (4), from the roots of Astragalusmicrocephalus have been isolated together with five known saponins, astragalosides I, II, and IV, cyclocanthoside E, and cycloastragenol. The structures of the new compounds were established as 3-O-[beta-D-xylopyranosyl(1-->3)-beta-D-xylopyranosyl-6-O-beta-D-gluc opyranosyl-3beta,6alpha,16beta,24(S),25-pentahydrox ycycloartane (1), 3-O-beta-D-xylopyranosyl-6-O-beta-D-glucopyranosyl-24-O-beta-D-glucop yranosyl-3beta,6alpha,16beta,24(S),25-pentahydroxyc ycloartane (2), 20(R),24(S)-epoxy-6-O-beta-D-glucopyranosyl-3beta,6alpha,16beta , 25-tetrahydroxycycloartane (3), and 20(R), 24(S)-epoxy-3-O-(4'-O-acetyl)-beta-D-xylopyranosyl-6-O-beta-D-glucopy ranosyl-3beta,6alpha,16beta,25-tetrahydroxycycloart ane (4). For the structure elucidations, 1D- and 2D-NMR experiments and FABMS were used.

Identifiers

DOI: 10.1021/np9801763

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