Article

A Multifunctional Zinc Oxide/Poly(Lactic Acid) Nanocomposite Layer Coated on Magnesium Alloys for Controlled Degradation and Antibacterial Function

Hamouda M. MousaDepartment of Bionanosystem Engineering, Division of Mechanical Design Engineering, Chonbuk National University, Jeonju, Jeonbuk 561-756, Republic of KoreaAbdalla Abdal‐hayDepartment of Engineering Materials and Mechanical Design, Faculty of Engineering, South Valley University, Qena 83523, EgyptMichal BartnikowskiThe University of Queensland, School of Dentistry, Oral Health Centre Herston, 288 Herston Road, Herston QLD 4006, AustraliaIbrahim M.A. MohamedDepartment of Bionanosystem Engineering, Division of Mechanical Design Engineering, Chonbuk National University, Jeonju, Jeonbuk 561-756, Republic of KoreaAhmed S. YasinDepartment of Bionanosystem Engineering, Division of Mechanical Design Engineering, Chonbuk National University, Jeonju, Jeonbuk 561-756, Republic of KoreaSašo IvanovskiThe University of Queensland, School of Dentistry, Oral Health Centre Herston, 288 Herston Road, Herston QLD 4006, AustraliaChan Hee ParkDepartment of Bionanosystem Engineering, Division of Mechanical Design Engineering, Chonbuk National University, Jeonju, Jeonbuk 561-756, Republic of KoreaCheol Sang KimDepartment of Bionanosystem Engineering, Division of Mechanical Design Engineering, Chonbuk National University, Jeonju, Jeonbuk 561-756, Republic of Korea

2018en

ABI

Abstract

In the present work, magnesium (Mg) AZ31 alloy was coated with a multifunctional membrane layer composed of ZnO nanoparticles (NPs) embedded in a poly(lactic acid) (PLA) matrix. We aimed to produce a stable coating that would be used to control the degradation rate of the Mg alloy and promote a local antibacterial activity. ZnO NPs were dispersed at 5 and 10 wt % in a PLA solution and dip-coated onto the AZ31 substrate. Surface topography, chemical composition, thickness, electrochemical corrosion performance, mass variation, antibacterial activity, adhesion performance, and cytotoxicity of an uncoated control and coated alloys were investigated. The results indicated that the incorporation of ZnO NPs at various concentrations affords a dramatic control over surface topography and degradation rates under in vitro and in vivo environmental conditions when compared to the uncoated Mg alloy control. In addition, the results confirmed that the coated layer exerts antibacterial properties and supports cell growth, indicating this system may have utility for bone tissue engineering applications.

Identifiers

DOI: 10.1021/acsbiomaterials.8b00277

Citations and references

Cited by 20 references

Metrics — AkademScholar