Article

Anticancer and Antioxidant Activities in Ganoderma lucidum Wild Mushrooms in Poland, as Well as Their Phenolic and Triterpenoid Compounds

Joanna Kolniak‐OstekDepartment of Fruit, Vegetable and Plant Nutraceutical Technology, Wrocław University of Environmental and Life Sciences, 37 Chełmońskiego Street, 51-630 Wroclaw, PolandJan OszmiańskiDepartment of Fruit, Vegetable and Plant Nutraceutical Technology, Wrocław University of Environmental and Life Sciences, 37 Chełmońskiego Street, 51-630 Wroclaw, PolandAnna SzyjkaDepartment of Basic Medical Sciences, Faculty of Pharmacy, Wroclaw Medical University, 211 Borowska Street, 50-556 Wrocław, PolandHelena MoreiraDepartment of Basic Medical Sciences, Faculty of Pharmacy, Wroclaw Medical University, 211 Borowska Street, 50-556 Wrocław, PolandEwa BargDepartment of Basic Medical Sciences, Faculty of Pharmacy, Wroclaw Medical University, 211 Borowska Street, 50-556 Wrocław, Poland

2022en

ABI

Abstract

The goal of this study was to the assess anti-cancer and antioxidant properties of the Ganoderma lucidum fruiting body, and to identify bioactive compounds found in their extracts. Significant antiproliferative activity was observed against MCF-7, MCF-7/DX, LOVO, LOVO/DX, MDA-MB 231, SW 620, and NHDF cell lines. With IC50 values of 25.38 µg/mL and 47.90 µg/mL, respectively, the extract was most effective against MDA-MB 231 and SW 620 cell lines. The bioactive compounds were identified using an ACQUITY UPLC-PDA-MS system. The extracts contained 13 triterpenoids and 28 polyphenols from the flavonols, phenolic acids, flavones, flavan-3-ols, and stilbenes families. Ganoderic acid derivative was found to be the most abundant triterpenoid (162.4 mg/g DW), followed by ganoderic acid B (145.6 mg/g DW). Resveratrol was the most abundant phenolic in the extract (5155.7 mg/100 g DM). The findings could explain why G. lucidum extracts are used in folk medicine.

Identifiers

DOI: 10.3390/ijms23169359

Citations and references

Cited by 20 references

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