Hypoxia and the Tumor Microenvironment
Yue LiClinical Medicine Postdoctoral Research Station, Jinan University, Guangzhou, Guangdong, ChinaLong ZhaoClinical Medicine Postdoctoral Research Station, Jinan University, Guangzhou, Guangdong, ChinaXiaofeng LiClinical Medicine Postdoctoral Research Station, Jinan University, Guangzhou, Guangdong, China
2021en
ABI
Abstract
Hypoxia is an important feature of the tumor microenvironment, and is closely associated with cell proliferation, angiogenesis, metabolism and the tumor immune response. All these factors can further promote tumor progression, increase tumor aggressiveness, enhance tumor metastatic potential and lead to poor prognosis. In this review, these effects of hypoxia on tumor biology will be discussed, along with their significance for tumor detection and treatment.
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