Recent Development of 1,2,4-triazole-containing Compounds as Anticancer Agents
Xiaoyue WenThe Institute of Infection and Inflammation, China Three Gorges University, Yichang, Hubei 443000, ChinaYong-qin ZhouThe Institute of Infection and Inflammation, China Three Gorges University, Yichang, Hubei 443000, ChinaJunhao ZengThe Institute of Infection and Inflammation, China Three Gorges University, Yichang, Hubei 443000, ChinaXinyue LiuThe Institute of Infection and Inflammation, China Three Gorges University, Yichang, Hubei 443000, China
2020en
ABI
Abstract
1,2,4-Triazole derivatives possess promising in vitro and in vivo anticancer activity, and many anticancer agents such as fluconazole, tebuconazole, triadimefon, and ribavirin bear a 1,2,4-triazole moiety, revealing their potential in the development of novel anticancer agents. This review emphasizes the recent advances in 1,2,4-triazole-containing compounds with anticancer potential, and the structureactivity relationships as well as mechanisms of action are also discussed.
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