The cytoskeleton and membrane transport
John W. MillsErik M. SchwiebertJohns Hopkins School of Medicine, Baltimore, Maryland, USABruce A. StantonDartmouth Medical School, Hanover, New Hampshire, USA
1994en
ABI
Abstract
This review summarizes recent studies demonstrating that the actin-based cytoskeleton regulates the activity of many ion channels and transport proteins. Stretch-activated ion channels; channels conductive to chloride, to sodium, and to potassium; electroneutral transport proteins, including the Na(+)-K(+)-2Cl-cotransporter, the Na+/H+ exchanger, and the organic osmolyte transporter; as well as water channels are all regulated by the actin cytoskeleton. Several potential mechanisms whereby the actin cytoskeleton and microtubules regulate transport protein activity are discussed.
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Cited by 20 references