Article

O<sub>2</sub> and N<sub>2</sub>O Activation by Bi-, Tri-, and Tetranuclear Cu Clusters in Biology

Edward I. SolomonDepartment of Chemistry, Stanford University, Stanford, California 94305Ritimukta SarangiDepartment of Chemistry, Stanford University, Stanford, California 94305Julia S. WoertinkDepartment of Chemistry, Stanford University, Stanford, California 94305Anthony J. AugustineDepartment of Chemistry, Stanford University, Stanford, California 94305Jungjoo YoonDepartment of Chemistry, Stanford University, Stanford, California 94305Somdatta Ghosh DeyDepartment of Chemistry, Stanford University, Stanford, California 94305

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ABI

Abstract

Copper-cluster sites in biology exhibit unique spectroscopic features reflecting exchange coupling between oxidized Cu's and e (-) delocalization in mixed valent sites. These novel electronic structures play critical roles in O 2 binding and activation for electrophilic aromatic attack and H-atom abstraction, the 4e (-)/4H (+) reduction of O 2 to H 2O, and in the 2e (-)/2H (+) reduction of N 2O. These electronic structure/reactivity correlations are summarized below.

Identifiers

DOI: 10.1021/ar600060t

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