Antimalarial Activity of Sesquiterpenes from the Marine Sponge Acanthella klethra
Cindy K. AngerhoferDepartment of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois, Chicago 60612John M. PezzutoGM KönigAnthony D. WrightOtto Sticher
1992en
ABI
Abstract
Five sesquiterpenoids containing isonitrile or isothiocyanate groups were isolated from the sponge Acanthella klethra. Compounds 1 and 2 were identified as axisonitrile 3 and the corresponding isothiocyanate derivative, respectively. Compounds 3-5 were found to be eudesmane sesquiterpenes. None of these compounds was cytotoxic toward cultured KB-3 cells, but varying degrees of activity were observed with cultured Plasmodium falciparum. Compound 1 demonstrated greatest promise as an antimalarial agent.
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