Bacterial Biofilms: A Common Cause of Persistent Infections
J. William CostertonCenter for Biofilm Engineering, Montana State University, Bozeman, MT 59717, USAPhilip S. StewartCenter for Biofilm Engineering, Montana State University, Bozeman, MT 59717, USAE. Peter GreenbergDepartment of Microbiology, University of Iowa, Iowa City, IA 52242, USA
1999en
ABI
Abstract
Bacteria that attach to surfaces aggregate in a hydrated polymeric matrix of their own synthesis to form biofilms. Formation of these sessile communities and their inherent resistance to antimicrobial agents are at the root of many persistent and chronic bacterial infections. Studies of biofilms have revealed differentiated, structured groups of cells with community properties. Recent advances in our understanding of the genetic and molecular basis of bacterial community behavior point to therapeutic targets that may provide a means for the control of biofilm infections.
Identifiers
Citations and references
Cited by 20 references