Investigation of Heck coupling on 6-bromo[2,3-d]thienopyrimidines for construction of new EGFR inhibitor lead structures
F. BystingDepartment of ChemistrySteffen BuggeDepartment of ChemistryEirik SundbyDepartment of Materials Science and EngineeringBård Helge HoffDepartment of Chemistry
2017en
ABI
Abstract
With the aim of identifying new lead structures for EGFR inhibition, a study of palladium catalysed Heck coupling between (<italic>R</italic>)-6-bromo-<italic>N</italic>-(1-phenylethyl)thieno[2,3-<italic>d</italic>]pyrimidin-4-amine and various acrylates was performed.
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