New Sphingolipids with a Previously Unreported 9‐Methyl‐C<sub>20</sub>‐sphingosine Moiety from a Marine Algous Endophytic Fungus <i>Aspergillus niger</i> EN‐13
Yi ZhangGraduate School of the Chinese Academy of Sciences Beijing 100039 People's Republic of ChinaSong WangGraduate School of the Chinese Academy of Sciences Beijing 100039 People's Republic of ChinaXiaoming LiKey Laboratory of Experimental Marine Biology Institute of Oceanology, Chinese Academy of Sciences Qingdao 266071 People's Republic of ChinaChuan‐Ming CuiGraduate School of the Chinese Academy of Sciences Beijing 100039 People's Republic of ChinaChao FengGraduate School of the Chinese Academy of Sciences Beijing 100039 People's Republic of ChinaBin‐Gui WangKey Laboratory of Experimental Marine Biology Institute of Oceanology, Chinese Academy of Sciences Qingdao 266071 People's Republic of China
2007en
ABI
Abstract
Asperamides A (1) and B (2), a sphingolipid and their corresponding glycosphingolipid possessing a hitherto unreported 9-methyl-C20-sphingosine moiety, were characterized from the culture extract of Aspergillus niger EN-13, an endophytic fungus isolated from marine brown alga Colpomenia sinuosa. The structures were elucidated by spectroscopic and chemical methods as (2S,2'R,3R,3'E,4E,8E)-N-(2'-hydroxy-3'-hexadecenoyl)-9-methyl-4,8-icosadien-1,3-diol (1) and 1-O-beta-D-glucopyranosyl-(2S,2'R,3R,3'E,4E,8E)-N-(2'-hydroxy-3'-hexadecenoyl)-9-methyl-4,8-icosadien-1,3-diol (2). In the antifungal assay, asperamide A (1) displayed moderate activity against Candida albicans.
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