TMC-171A, B, C and TMC-154, Novel Polyketide Antibiotics Produced by Gliocledjum sp. TC 1304 and TC 1282.
Jun KohnoDiscovery Research Laboratory, Tanabe Seiyaku Co., Ltd., Toda-shi, Saitama, JapanYasuyuki AsaiDiscovery Research Laboratory, Tanabe Seiyaku Co., LtdMAKI NISHIODiscovery Research Laboratory, Tanabe Seiyaku Co., LtdMasaaki SakuraiDiscovery Research Laboratory, Tanabe Seiyaku Co., LtdKimio KawanoDiscovery Research Laboratory, Tanabe Seiyaku Co., LtdHajime HiramatsuDiscovery Research Laboratory, Tanabe Seiyaku Co., LtdNoriaki KamedaDiscovery Research Laboratory, Tanabe Seiyaku Co., LtdNoboru KishiDiscovery Research Laboratory, Tanabe Seiyaku Co., LtdTôru OkudaDiscovery Research Laboratory, Tanabe Seiyaku Co., LtdSaburo KomatsubaraDiscovery Research Laboratory, Tanabe Seiyaku Co., Ltd
1999en
ABI
Abstract
Four new antibiotics, TMC-171A (2), B (3), C (4) and TMC-154 (5) have been isolated from the fermentation of fungal strains Gliocladium sp. TC 1304 and TC 1282, respectively. Spectroscopic and degradation studies have shown that TMC-171s and TMC-154 were new members of the TMC-151 class of antibiotics, unique polyketides modified with a D-mannose and a D-mannitol or a D-arabitol. These compounds showed moderate cytotoxicity to various tumor cell lines.
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