KS-501 and KS-502, new inhibitors of Ca2+ and calmodulin-dependent cyclic-nucleotide phosphodiesterase from Sporothrix sp.
Satoshi NakanishiTokyo Research Laboratories, Kyowa Hakko Kogyo Co., Ltd., JapanKatsuhiko AndoTokyo Research Laboratories, Kyowa Hakko Kogyo Co., LtdIsao KawamotoTokyo Research Laboratories, Kyowa Hakko Kogyo Co., LtdHiroshi KaseTokyo Research Laboratories, Kyowa Hakko Kogyo Co., Ltd
1989en
ABI
Abstract
New inhibitors of Ca2+ and calmodulin-dependent cyclic-nucleotide phosphodiesterase, KS-501 and KS-502 were isolated from a fungus, Sporothrix sp. KAC-1985. Inhibitory concentration causing 50% inhibition (IC50) values of KS-501 and KS-502 for bovine brain enzyme were 1.8 and 4.3 microM, respectively. The compounds exhibited no or weak inhibition for calmodulin-independent cyclic-nucleotide phosphodiesterases and protein kinase C.
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