ISOLATION OF A TUMOR FACTOR RESPONSIBLE FOR ANGIOGENESIS
Judah FolkmanFrom the Departments of Surgery and Pediatrics, Children's Hospital Medical Center and Harvard Medical School, Boston, Massachusetts 02115Ezio MerlerFrom the Departments of Surgery and Pediatrics, Children's Hospital Medical Center and Harvard Medical School, Boston, Massachusetts 02115Charles M. AbernathyFrom the Departments of Surgery and Pediatrics, Children's Hospital Medical Center and Harvard Medical School, Boston, Massachusetts 02115Gretchen M. WilliamsHarvard University
1971en
ABI
Abstract
Human and animal solid tumors elaborate a factor which is mitogenic to capillary endothelial cells. This factor has been called tumor-angiogenesis factor. The important components of TAF are RNA and protein. It is suggested that blockade of this factor (inhibition of angiogenesis) might arrest solid tumors at a tiny diameter of a few millimeters.
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