Antitumor Active Fucoidan from the Brown Seaweed,<i>Umitoranoo</i>(<i>Sargassum thunbergii</i>)
Cun ZhuangGifu UniversityHiroko ItohLaboratory of Marine Biochemistry, Faculty of Bioresources, Mie University, Tsu, Mie 514, JapanTakashi MizunoDepartment of Applied Biological Chemistry, Faculty of Agriculture, Shizuoka University, 843 Ohya, Shizuoka 422, JapanHitoshi ItoDepartment of Pharmacology, School of Medicine, Mie University, Tsu, Mie 514, Japan
1995en
ABI
Abstract
Neutral and acidic polysaccharides and their protein complexes were fractionated and purified from the brown seaweed umitoranoo (Sargassum thunbergii) by fractional extraction, iron-exchange chromatography, and gel filtration. Thirty-one polysaccharide fractions were obtained and tested for antitumor activity in mice with Ehrlich carcinoma transplanted i.p. Two of the fractions, GIV-A ([alpha]25D -127 degrees and mol. wt., 19,000) and GIV-B ([alpha]25D -110 degrees and mol. wt., 13,500) had such activity. On the basis of chemical and spectral analyses, these compounds were found to be a fucoidan or L-fucan containing approx. 30% sulfate ester groups per fucose residue, about 10% uronic acid, and less than 2% protein.
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