Review article

Recent Advances in Aptasensor for Cytokine Detection: A Review

Jinmyeong KimDepartment of Chemical Engineering, Kwangwoon University, 20 Kwangwoon-Ro, Nowon-gu, Seoul 01897, KoreaSeungwoo NohDepartment of Chemical Engineering, Kwangwoon University, 20 Kwangwoon-Ro, Nowon-gu, Seoul 01897, KoreaJeong Ah ParkDepartment of Chemical Engineering, Kwangwoon University, 20 Kwangwoon-Ro, Nowon-gu, Seoul 01897, KoreaSang Chan ParkDepartment of Electrical Engineering, Kwangwoon University, 20 Kwangwoon-Ro, Nowon-gu, Seoul 01897, KoreaSeong Jun ParkDepartment of Electrical Engineering, Kwangwoon University, 20 Kwangwoon-Ro, Nowon-gu, Seoul 01897, KoreaJin‐Ho LeeSchool of Biomedical Convergence Engineering, Pusan National University, 49 Busandaehak-ro, Yangsan 50612, KoreaJae‐Hyuk AhnDepartment of Electronics Engineering, Chungnam National University, 99 Yuseong-gu, Daejeon 34134, KoreaTaek LeeDepartment of Chemical Engineering, Kwangwoon University, 20 Kwangwoon-Ro, Nowon-gu, Seoul 01897, Korea

2021en

ABI

Abstract

Cytokines are proteins secreted by immune cells. They promote cell signal transduction and are involved in cell replication, death, and recovery. Cytokines are immune modulators, but their excessive secretion causes uncontrolled inflammation that attacks normal cells. Considering the properties of cytokines, monitoring the secretion of cytokines in vivo is of great value for medical and biological research. In this review, we offer a report on recent studies for cytokine detection, especially studies on aptasensors using aptamers. Aptamers are single strand nucleic acids that form a stable three-dimensional structure and have been receiving attention due to various characteristics such as simple production methods, low molecular weight, and ease of modification while performing a physiological role similar to antibodies.

Identifiers

DOI: 10.3390/s21248491

Citations and references

Cited by 20 references

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