New Bisoxazoline Ligands Enable Enantioselective Electrocatalytic Cyanofunctionalization of Vinylarenes
Niankai FuDepartment of Chemistry and Chemical Biology, Cornell University, Ithaca, New York 14853, United StatesSong LuDepartment of Chemistry and Chemical Biology, Cornell University, Ithaca, New York 14853, United StatesJinjian LiuDepartment of Chemistry and Chemical Biology, Cornell University, Ithaca, New York 14853, United StatesYifan ShenDepartment of Chemistry and Chemical Biology, Cornell University, Ithaca, New York 14853, United StatesJuno C. SiuDepartment of Chemistry and Chemical Biology, Cornell University, Ithaca, New York 14853, United StatesSong LinDepartment of Chemistry and Chemical Biology, Cornell University, Ithaca, New York 14853, United States
2019en
ABI
Abstract
In contrast to the rapid growth of synthetic electrochemistry in recent years, enantioselective catalytic methods powered by electricity remain rare. In this work, we report the development of a highly enantioselective method for the electrochemical cyanophosphinoylation of vinylarenes. A new family of serine-derived chiral bisoxazolines with ancillary coordination sites were identified as optimal ligands.
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