Solubility of Aspirin in Supercritical Carbon Dioxide with and without Acetone
Zhen HuangDepartment of Chemical & Environmental Engineering, National University of Singapore, 10 Kent Ridge Crescent, 119260 Singapore, and Department of Chemical & Biochemical Engineering, Rutgers University, Piscataway, New Jersey 08854Wei LüDepartment of Chemical & Environmental Engineering, National University of Singapore, 10 Kent Ridge Crescent, 119260 Singapore, and Department of Chemical & Biochemical Engineering, Rutgers University, Piscataway, New Jersey 08854Sibudjing KawiDepartment of Chemical & Environmental Engineering, National University of Singapore, 10 Kent Ridge Crescent, 119260 Singapore, and Department of Chemical & Biochemical Engineering, Rutgers University, Piscataway, New Jersey 08854Yee C. ChiewDepartment of Chemical & Environmental Engineering, National University of Singapore, 10 Kent Ridge Crescent, 119260 Singapore, and Department of Chemical & Biochemical Engineering, Rutgers University, Piscataway, New Jersey 08854
2004en
ABI
Abstract
The equilibrium solubility of aspirin in supercritical CO2 has been determined using a dynamic method. Measurements were performed at pressures ranging from (10 to 25) MPa and temperatures from (308.15 to 328.15) K. The effect of a polar cosolvent, acetone, on the solubility of aspirin in supercritical carbon dioxide was also studied. The results show that the addition of acetone produces up to a 5-fold increase in the aspirin solubility. The solubility of aspirin in CO2 is well described by the Peng−Robinson equation of state and density based correlations over the pressure and temperature ranges studied.
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