Article

Evaluation of bioactive release kinetics from crosslinked chitosan films with Aloe vera

Iratxe ZarandonaBIOMAT Research Group, University of the Basque Country (UPV/EHU), Escuela de Ingeniería de Gipuzkoa, Plaza de Europa 1, 20018 Donostia-San Sebastián, SpainNguyên Công MinhFaculty of Food Technology, Nha Trang University, 02 Nguyen Dinh Chieu Street, Nha Trang City 650000, Viet NamTrang Sĩ TrungFaculty of Food Technology, Nha Trang University, 02 Nguyen Dinh Chieu Street, Nha Trang City 650000, Viet NamKoro de la CabaBIOMAT Research Group, University of the Basque Country (UPV/EHU), Escuela de Ingeniería de Gipuzkoa, Plaza de Europa 1, 20018 Donostia-San Sebastián, Spain; BCMaterials, Basque Center for Materials, Applications and Nanostructures, UPV/EHU Science Park, 48940 Leioa, Spain. Electronic address: [email protected]Pedro GuerreroBIOMAT Research Group, University of the Basque Country (UPV/EHU), Escuela de Ingeniería de Gipuzkoa, Plaza de Europa 1, 20018 Donostia-San Sebastián, Spain; BCMaterials, Basque Center for Materials, Applications and Nanostructures, UPV/EHU Science Park, 48940 Leioa, Spain. Electronic address: [email protected]

2021en

ABI

Abstract

Thermocompression was employed to prepare citric acid-crosslinked chitosan films with Aloe vera (AV) as bioactive compound. Films were easy to handle and mechanical properties did not change with the addition of AV up to 10 wt%, although both TS and EAB decreased for the films with 15 wt% AV, indicating that high AV contents would hinder intermolecular interactions among the formulation components. Maillard reaction occurred between chitosan and citric acid at the processing temperature used (115 °C), while physical interactions took place with AV, as shown by FTIR analysis. All films were insoluble but displayed hydration and limited swelling due to both physical and chemical interactions promoted by AV and citric acid, respectively. A slow AV release, governed by a Fickian diffusion controlled mechanism, and an increase of surface hydrophilicity, which favors cell adhesion, were observed.

Identifiers

DOI: 10.1016/j.ijbiomac.2021.05.087

Citations and references

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