Photosensitizer effects of MWCNTs-COOH particles on CT26 fibroblastic cells exposed to laser irradiation
Nouraddin Abdi GoushbolaghMedical Physics Department, Faculty of Medicine, Shahid Sadoughi University of Medical SciencesMarzieh KeshavarzDepartment of Medical Physics, School of Medicine, Iran University of Medical SciencesMohammad Hosein ZareMedical Physics Department, Faculty of Medicine, Shahid Sadoughi University of Medical SciencesMohammad Hossein Bahreyni-ToosiMedical Physics Research Center, Bu Ali Research Institute, Mashad University of Medical SciencesMasoud KargarMedical Physics Department, Faculty of Medicine, Shahid Sadoughi University of Medical SciencesBagher FarhoodDepartment of Medical Physics and Radiology, Faculty of Paramedical Sciences, Kashan University of Medical Sciences
2019en
ABI
Abstract
). It was shown that using the 80 μg/mL concentration of MWCNTs-COOH against 60, 120, 180, 240, and 300 s of NIR irradiation and also, 10 and 50 μg/mL concentration of MWCNTs-COOH against 180, 240, and 300 s of NIR irradiation can lead to significant decrease in mean cell viability (%) by more than 50%. According to the obtained data, it seems that using the PPT with MWCNTs-COOH, as adjunct therapy in CT26 fibroblastic cells, can help to increase therapeutic ratio of main modalities of cancer treatment such as radiotherapy, chemotherapy, and surgery.
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