Article

Autologous NK cells as consolidation therapy following stem cell transplantation in multiple myeloma

Hareth NahiCenter for Hematology and Regenerative Medicine, Department of Medicine Huddinge, Karolinska Institutet, SE-14183 Huddinge, SwedenMichael ChrobokCenter for Hematology and Regenerative Medicine, Department of Medicine Huddinge, Karolinska Institutet, SE-14183 Huddinge, SwedenStephan MeinkeCenter for Hematology and Regenerative Medicine, Department of Medicine Huddinge, Karolinska Institutet, SE-14183 Huddinge, SwedenCharlotte GranCenter for Hematology and Regenerative Medicine, Department of Medicine Huddinge, Karolinska Institutet, SE-14183 Huddinge, SwedenNicole MarquardtCenter for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, SE-14183 Huddinge, SwedenGabriel AframCenter for Hematology and Regenerative Medicine, Department of Medicine Huddinge, Karolinska Institutet, SE-14183 Huddinge, SwedenTolga SütlüCenter for Hematology and Regenerative Medicine, Department of Medicine Huddinge, Karolinska Institutet, SE-14183 Huddinge, SwedenMari GilljamCenter for Hematology and Regenerative Medicine, Department of Medicine Huddinge, Karolinska Institutet, SE-14183 Huddinge, SwedenBirgitta StellanCenter for Hematology and Regenerative Medicine, Department of Medicine Huddinge, Karolinska Institutet, SE-14183 Huddinge, SwedenArnika Kathleen WagnerCenter for Hematology and Regenerative Medicine, Department of Medicine Huddinge, Karolinska Institutet, SE-14183 Huddinge, SwedenPontus BlombergVecura, Department of Laboratory Medicine, Karolinska Institutet, SE-14186 Stockholm, SwedenPer-Henrik HolmqvistVecura, Karolinska Cell Therapy Center, Karolinska University Hospital, SE-14186 Stockholm, SwedenLilian Walther–JallowDepartment of Clinical Science, Intervention and Technology, Karolinska Institutet, SE-14183 Huddinge, SwedenKarin MellströmJohan LiwingCharlotte GustafssonCenter for Hematology and Regenerative Medicine, Division of Clinical Immunology and Transfusion Medicine, Department of Laboratory Medicine, Karolinska Institutet, SE-14183 Huddinge, SwedenRobert MånssonCenter for Hematology and Regenerative Medicine, Division of Clinical Immunology and Transfusion Medicine, Department of Laboratory Medicine, Karolinska Institutet, SE-14183 Huddinge, SwedenMonika KlimkowskaDepartment of Clinical Pathology and Cytology, Karolinska University Hospital, SE-14186 Huddinge, SwedenGösta GahrtonCenter for Hematology and Regenerative Medicine, Department of Medicine Huddinge, Karolinska Institutet, SE-14183 Huddinge, SwedenJohan LundCenter for Hematology and Regenerative Medicine, Department of Medicine Huddinge, Karolinska Institutet, SE-14183 Huddinge, SwedenPer LjungmanDepartment of Cellular Therapy and Allogeneic Stem Cell Transplantation, Karolinska University Hospital Huddinge, SE-14186 Huddinge, SwedenHans‐Gustaf LjunggrenCenter for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, SE-14183 Huddinge, SwedenEvren AliciCenter for Hematology and Regenerative Medicine, Department of Medicine Huddinge, Karolinska Institutet, SE-14183 Huddinge, Sweden

2022en

ABI

Abstract

activated and expanded autologous NK cells in patients with multiple myeloma (MM) post-autologous stem cell transplantation. Infused NK cells were detected in circulation up to 4 weeks after the last infusion. Elevations in plasma granzyme B levels were observed following each consecutive NK cell infusion. Moreover, increased granzyme B levels were detected in bone marrow 4 weeks after the last infusion. All measurable patients had objective, detectable responses after NK cell infusions in terms of reduction in M-component and/or minimal residual disease. The present study demonstrates that autologous NK cell-based immunotherapy is feasible in a setting of MM consolidation therapy. It opens up the possibility for usage of autologous NK cells in clinical settings where patients are not readily eligible for allogeneic NK cell-based immunotherapies.

Identifiers

DOI: 10.1016/j.xcrm.2022.100508

Citations and references

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