Tumor-Associated Macrophages Press the Angiogenic Switch in Breast Cancer
Elaine Y. Lin2Department of Medicine, Oncology Division, Albert Einstein Cancer Center, Albert Einstein College of Medicine, Bronx, New YorkJeffrey W. Pollard1Department of Developmental and Molecular Biology, Center of Reproductive Biology and Women's Health and
2007en
ABI
Abstract
The development of a supportive vasculature is essential for tumor progression. In a mouse model of breast cancer, we found that tumor-associated macrophages that are recruited to the tumor just before malignant conversion are essential for the angiogenic switch. These findings establish a causal linkage to explain well-documented clinical correlations between macrophages, microvessel density, and poor prognosis in breast tumors.
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