Circular RNA RHOT1 promotes progression and inhibits ferroptosis via mir-106a-5p/STAT3 axis in breast cancer
Huiming ZhangDepartment of General Surgery, Beijing Friendship Hospital, Capital Medical University, Beijing, ChinaZhicheng GeDepartment of General Surgery, Beijing Friendship Hospital, Capital Medical University, Beijing, ChinaZihan WangDepartment of General Surgery, Beijing Friendship Hospital, Capital Medical University, Beijing, ChinaYinguang GaoDepartment of General Surgery, Beijing Friendship Hospital, Capital Medical University, Beijing, ChinaYang WangDepartment of General Surgery, Beijing Friendship Hospital, Capital Medical University, Beijing, ChinaXiang QuDepartment of General Surgery, Beijing Friendship Hospital, Capital Medical University, Beijing, China
2021en
ABI
Abstract
. In conclusion, we discovered that circRHOT1 contributed to malignant progression and attenuated ferroptosis in breast cancer by the miR-106a-5p/STAT3 axis. Our finding provides new insights into the mechanism by which circRHOT1 promotes the development of breast cancer. CircRHOT1 and miR-106a-5p may serve as potential targets for breast cancer therapy.
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