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Article

KNN-based single crystal high frequency transducer for intravascular photoacoustic imaging

Benpeng ZhuDepartment of Biomedical Engineering, University of Southern California, Los Angeles, USAWei WeiHubei Cancer Hospital, Wuhan, ChinaYongxiang LiKey Laboratory of Inorganic Functional Materials and Devices, Chinese Academy of Sciences, Shanghai, ChinaXiaofei YangSchool of Optical and Electronic Information, Huazhong University of Science and Technology, Wuhan, ChinaQifa ZhouDepartment of Biomedical Engineering, University of Southern California, Los Angeles, USAK. Kirk ShungDepartment of Biomedical Engineering, University of Southern California, Los Angeles, USA
2017en
ABI

Abstract

With its thickness decreasing down to 60 μm, the (K <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">0.45</sub> Na <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">0.55</sub> ) <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">0.96</sub> Li <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">0.04</sub> NbO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> (KNLN) single crystals maintains superior piezoelectric constant (d <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">33</sub> = 675 pC N <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-1</sup> ). In combination with a 200 μm core multimode fiber, the successful fabrication of a tiny intravascular photoacoustic probe with a 1 mm outside diameter is achieved. The intravascular photoacoustic imaging of the atherosclerotic lesion of a human artery is presented. In the time-domain and frequency-domain images, calcified regions are clearly distinguishable from surrounding tissue. These interesting results demonstrate that KNN-based lead-free piezoelectric single crystals are a promising candidate to substitute for lead-based piezoelectric materials for photoacoustic imaging in the future.

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