The interaction between ferroptosis and lipid metabolism in cancer
Dingshan LiClinical Medicine Research Center, Xinqiao Hospital, Army Medical University, Chongqing, 400037, ChinaYongsheng LiClinical Medicine Research Center, Xinqiao Hospital, Army Medical University, Chongqing, 400037, China. [email protected]
2020en
ABI
Abstract
Ferroptosis is a new form of programmed cell death characterized by the accumulation of iron-dependent lethal lipid peroxides. Recent discoveries have focused on alterations that occur in lipid metabolism during ferroptosis and have provided intriguing insights into the interplay between ferroptosis and lipid metabolism in cancer. Their interaction regulates the initiation, development, metastasis, therapy resistance of cancer, as well as the tumor immunity, which offers several potential strategies for cancer treatment. This review is a brief overview of the features characterizing the interaction between ferroptosis and lipid metabolism, and highlights the significance of this interaction in cancer.
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