Operative conversions of 3-carboxy-4-quinolones into 3-nitro-4-quinolones <i>via ipso</i>-nitration: potential antifilarial agents as inhibitors of <i>Brugia malayi</i> thymidylate kinase
Chandra S. AzadDivision of Medicinal and Process Chemistry CSIR-Central Drug Research InstituteVishal M. BalaramnavarGlobal Institute of Pharmaceutical Education and ResearchImran A. KhanDivision of Medicinal and Process Chemistry CSIR-Central Drug Research InstitutePawan Kumar DohareyCSIR-Central Drug Research InstituteJitendra Kumar SaxenaCSIR-Central Drug Research InstituteAnil K. SaxenaDivision of Medicinal and Process Chemistry CSIR-Central Drug Research Institute
2015en
ABI
Abstract
An efficient, cost effective and green methodology for <italic>ipso</italic> nitration in the synthesis of the 3-nitro derivative of 3-carboxy 4-quinolones has been developed by the quantitative use of copper acetate and silver nitrate in water.
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